Butyrate restores motile function and actin cytoskeletal network integrity in apc mutated mouse colon epithelial cells.
Nutr Cancer
; 45(1): 84-92, 2003.
Article
em En
| MEDLINE
| ID: mdl-12791508
ABSTRACT
Loss of function of the Apc gene product is an early and frequent event in colorectal carcinogenesis. Altered migration of intestinal epithelial cells has been described in vivo in the Min mouse Apc+/Min model. Using cell lines established from this model we show in vitro that Apc+/Min cells are less motile than Apc+/+ cells and exhibit a disordered actin cytoskeletal network. This would increase the probabilities of the initiated cell to acquire additional genetic alterations leading to neoplasia. Butyrate, a product of indigestible carbohydrate fermentation by the colonic flora, is able to restore both motility and actin cytoskeletal organization. This feature may contribute to explain the protective effect exerted by butyrogenic diets on colon carcinogenesis in animal models.
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Base de dados:
MEDLINE
Assunto principal:
Citoesqueleto
/
Butiratos
/
Neoplasias Colorretais
/
Actinas
/
Genes APC
/
Proteína da Polipose Adenomatosa do Colo
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Nutr Cancer
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
França