Early postnatal behavior deficits after maternal carbon dioxide pneumoperitoneum during pregnancy.
Surg Endosc
; 17(11): 1823-5, 2003 Nov.
Article
em En
| MEDLINE
| ID: mdl-12802645
ABSTRACT
BACKGROUND:
In this study, we tested the hypothesis that maternal pneumoperitoneum produces early postnatal behavior deficits in the offspring.METHODS:
Time-dated pregnant guinea pigs were exposed to 45 min of carbon dioxide (CO2) pneumoperitoneum at a pressure of 7 mmHg. There was no manipulation of the control animals. On postnatal days (PND) 10 and 20, the behavior of their offspring was assessed by monitoring the locomotor activity of each of the pups in a 1 x 1 m chamber demarcated into 100 squares. Locomotor data was log-transformed and expressed as mean values (SD).RESULTS:
At PND 10, pneumoperitoneum offspring exhibited significantly higher levels of locomotor activity than the offspring of controls (1.81 +/- 0.48 vs 1.33 +/- 0.78). The pneumoperitoneum pups continued to exhibit hyperactive behavior at PND 20 (1.83 +/- 0.72 vs 1.20 +/- 0.72).CONCLUSIONS:
Maternal pneumoperitoneum produces postnatal hyperactivity in guinea pig offspring, suggesting that there may be long-term consequences associated with the physiologic changes produced in the fetus during CO2 insufflation.
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Base de dados:
MEDLINE
Assunto principal:
Pneumoperitônio Artificial
/
Efeitos Tardios da Exposição Pré-Natal
/
Dióxido de Carbono
/
Feto
/
Hipercinese
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Surg Endosc
Assunto da revista:
DIAGNOSTICO POR IMAGEM
/
GASTROENTEROLOGIA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos