Altered proteinogram in short term portal vein stenosed rats.
Chin J Physiol
; 45(2): 89-93, 2002 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-12817722
ABSTRACT
The electrophoretic pattern of serum proteins has been studied in short-term prehepatic portal hypertensive rats since atrophy is produced in the liver, which is the main origin of most of these proteins, during this postoperative period. After 28 days of evolution, rats (n = 9) with triple stenosing ligated portal vein showed hypoalbuminemia, hypo-alpha-globulinemia, hyper-alpha2-globulinemia and hyper-gamma-globulinemia, the albumin/globulin ratio decreased with respect to the control animals (n = 8). These alterations are associated with hepatic atrophy, portosystemic and portohepatic (44.4%) collateral circulation. The proteinogram alterations found in rats with short-term prehepatic portal hypertension suggest that hepatic failure exists in spite of potential portohepatic revascularization which is frequently originated by the development of portohepatic collateral circulation.
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Base de dados:
MEDLINE
Assunto principal:
Veia Porta
/
Albumina Sérica
/
Soroglobulinas
/
Hipertensão Portal
Limite:
Animals
Idioma:
En
Revista:
Chin J Physiol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Espanha