Identification of RIP140 as a nuclear receptor cofactor with a role in female reproduction.
FEBS Lett
; 546(1): 149-53, 2003 Jul 03.
Article
em En
| MEDLINE
| ID: mdl-12829251
ABSTRACT
Nuclear receptors function as ligand-dependent transcription factors by recruiting cofactors that remodel chromatin and recruit the transcription machinery. RIP140 (receptor interacting protein with a molecular weight of 140 kDa) is a widely expressed corepressor that has the potential to inhibit the transcriptional activity of most, if not all nuclear receptors. Mice devoid of RIP140 indicate that it plays a crucial role in female fertility and in adipose biology. It is essential in the ovary for ovulation, specifically oocyte release but not luteinisation of mature follicles. Our goal is to identify the key nuclear receptor(s) and their target genes responsible for ovulation.
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Base de dados:
MEDLINE
Assunto principal:
Reprodução
/
Proteínas Nucleares
/
Receptores Citoplasmáticos e Nucleares
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Reino Unido