[Preventive effects of exercise training on bone loss during 21 d -6 degrees head down bed-rest].

ABSTRACT

OBJECTIVE: To observe the protective effects of exercise training during 21 d -6 degrees head down bed rest (HDBR) on bone loss. METHOD: Ten healthy young men were randomly divided into HDBR group and HD-BR exercise group, with 5 in each group. Both groups were exposed to -6 degrees head down bed rest for 21 d. The subjects in the exercise group performed exercise with a bicycle ergometer in supine position 1 h/d during bed rest. Femur bone mineral density (BMD), serum bone gla protein (BGP) as well as hydroxyproline/creatinine (HOP/Cr) were determined before and during 20 d HDBR. RESULT: As compared with the before HDBR values, average femur BMD decreased by 5.8% and 0.9% for HDBR group and HDBR and exercise group respectively. HOP/Cr significantly increased in the HDBR group and was significantly higher than the HDBR exercise group. BGP decreased in both groups with no significant difference. CONCLUSION: Exercise during 21 d -6 degrees HDBR is beneficial in preventing bone loss.