Experimental pulmonary aspergillosis due to Aspergillus terreus: pathogenesis and treatment of an emerging fungal pathogen resistant to amphotericin B.
J Infect Dis
; 188(2): 305-19, 2003 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-12854088
ABSTRACT
Aspergillus terreus is an uncommon but emerging fungal pathogen, which causes lethal infections that are often refractory to amphotericin B (AmB). In comparison to Aspergillus fumigatus, A. terreus was resistant to the in vitro fungicidal effects of safely achievable concentrations of AmB. These in vitro findings correlated directly with resistance of A. terreus to AmB in experimental invasive pulmonary aspergillosis. Residual fungal pulmonary burden and galactomannan antigenemia demonstrated persistent infection, despite therapy with deoxycholate AmB or liposomal AmB. By comparison, posaconazole and itraconazole resolved GM antigenemia, reduced residual fungal burden, and improved survival. There were no differences in phagocytic host response to A. terreus versus A. fumigatus; however, the rate of conidial germination of A. terreus was slower. The strain of A. terreus with the highest minimum inhibitory and minimum lethal concentration of AmB also had the lowest membrane ergosterol content. The hyphae of A. terreus in vivo displayed distinctive aleurioconidia, which may be a practical microscopic feature for rapid preliminary diagnosis.
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Base de dados:
MEDLINE
Assunto principal:
Aspergilose
/
Aspergillus
/
Anfotericina B
/
Doenças Transmissíveis Emergentes
/
Farmacorresistência Fúngica
/
Antifúngicos
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos