Negative regulation of cytokine signaling and inflammatory diseases.
Curr Opin Pharmacol
; 3(4): 435-42, 2003 Aug.
Article
em En
| MEDLINE
| ID: mdl-12901954
ABSTRACT
Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. These cytokines exert their biological functions through Janus tyrosine kinases and signal transducer and activators of transcription (STATs). The cytokine-inducible SH2 proteins (CIS) and suppressors of cytokine signaling (SOCS) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory system. Several recent advances have been made in this field, including treatment of inflammatory diseases by modulating extracellular and intracellular signaling pathways.
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Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Citocinas
/
Inflamação
Limite:
Animals
Idioma:
En
Revista:
Curr Opin Pharmacol
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Japão