A gene recommender algorithm to identify coexpressed genes in C. elegans.
Genome Res
; 13(8): 1828-37, 2003 Aug.
Article
em En
| MEDLINE
| ID: mdl-12902378
ABSTRACT
One of the most important uses of whole-genome expression data is for the discovery of new genes with similar function to a given list of genes (the query) already known to have closely related function. We have developed an algorithm, called the gene recommender, that ranks genes according to how strongly they correlate with a set of query genes in those experiments for which the query genes are most strongly coregulated. We used the gene recommender to find other genes coexpressed with several sets of query genes, including genes known to function in the retinoblastoma complex. Genetic experiments confirmed that one gene (JC8.6) identified by the gene recommender acts with lin-35 Rb to regulate vulval cell fates, and that another gene (wrm-1) acts antagonistically. We find that the gene recommender returns lists of genes with better precision, for fixed levels of recall, than lists generated using the C. elegans expression topomap.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
/
Regulação da Expressão Gênica
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Genes de Helmintos
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Caenorhabditis elegans
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Perfilação da Expressão Gênica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Genome Res
Assunto da revista:
BIOLOGIA MOLECULAR
/
GENETICA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos