Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity.
Bioorg Med Chem Lett
; 13(18): 3041-4, 2003 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-12941329
ABSTRACT
We have discovered that polar 7-substituents of pyridopyrimidine derivatives affect not only whole cell AK inhibitory potency, but also selectivity in causing locomotor side effects in vivo animal models. We have identified compound, 1o, which has potent whole cell AK inhibitory potency, analgesic activity and minimal reduction of locomotor activity.
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Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Adenosina Quinase
/
Analgésicos
/
Atividade Motora
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos