The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice.
Science
; 257(5068): 398-401, 1992 Jul 17.
Article
em En
| MEDLINE
| ID: mdl-1321503
ABSTRACT
Lethargic (lh/lh) mice, which function as an animal model of absence seizures, have spontaneous seizures that have behavioral and electrographic features and anticonvulsant sensitivity similar to those of human absence seizures. Antagonists of the gamma-aminobutyric acidB (GABAB) receptor suppressed these seizures in lethargic mice, whereas agonists of GABAB receptors exacerbated them. Furthermore, GABAB receptor binding and synaptically evoked GABAB receptor-mediated inhibition of N-methyl-D-aspartate responses were selectively increased in lh/lh mice. Therefore, enhanced GABAB receptor-mediated synaptic responses may underlie absence seizures in lh/lh mice, and GABAB receptor antagonists hold promise as anticonvulsants for absence seizures.
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Base de dados:
MEDLINE
Assunto principal:
Epilepsia Tipo Ausência
/
Receptores de GABA-A
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Nova Caledônia