The toxicity of macrocyclic trichothecenes administered directly into the rat brain.
Toxicon
; 30(10): 1291-4, 1992 Oct.
Article
em En
| MEDLINE
| ID: mdl-1440632
ABSTRACT
The tested macrocyclic trichothecenes are produced by Myrothecium fungi and by the plant Baccharis megapotamica. The toxicity of five macrocyclic trichothecenes has been measured by intracerebral and subcutaneous injection into rats. It is assumed that the toxic effects are based on inhibition of protein synthesis. Intoxication of rats by these compounds finds expression in slowly progressing respiratory depression and paralysis of skeletal muscles. The macrocyclics are derived from verrucarol, which lacks ring D and exhibits only low toxicity. The high toxicity of the macrocyclics, established by intracerebral and subcutaneous applications, may thus be attributed to the presence of the large ring D.
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Base de dados:
MEDLINE
Assunto principal:
Tricotecenos
Limite:
Animals
Idioma:
En
Revista:
Toxicon
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Israel