Innate resistance to new antimalarial drugs in Plasmodium falciparum from Nigeria.
Trans R Soc Trop Med Hyg
; 86(2): 123-6, 1992.
Article
em En
| MEDLINE
| ID: mdl-1440764
ABSTRACT
The rapid dissemination of chloroquine-resistant Plasmodium falciparum in West Africa has been well documented and represents a significant health threat to autochthonous populations. The methodical development of alternative chemotherapeutic agents demands that dispensing new antimalarial drugs (mefloquine, halofantrine, and artemisinine [qinghaosu]) be closely monitored in order to protect their clinical utility. Indeed, mefloquine-resistant strains of P. falciparum have been reported. We present data from experiments in vitro on the innate resistance of P. falciparum isolates to mefloquine as well as a disturbing observation of transient resistance to artemisinine. The implications for the extended efficacy of these new antimalarial drugs are addressed.
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Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Mefloquina
/
Malária Falciparum
/
Artemisininas
Limite:
Animals
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
Trans R Soc Trop Med Hyg
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Nigéria