First total synthesis and stereochemical definition of isodomoic acid G.
Org Lett
; 5(20): 3771-3, 2003 Oct 02.
Article
em En
| MEDLINE
| ID: mdl-14507227
ABSTRACT
[structure see text] The first total synthesis and stereochemical definition of isodomoic acid G has been achieved. The key nickel-catalyzed coupling of an alkynyl enone with an alkenylzirconium allows formation of the pyrrolidine ring and most of the stereochemical features in a single step. This report provides the first total synthesis application of this new reaction and illustrates its utility in the stereoselective preparation of highly substituted 1,3-dienes.
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Base de dados:
MEDLINE
Assunto principal:
Ácido Caínico
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos