Extremely rapid turnover of S-adenosylmethionine decarboxylase in Crithidia fasciculata.
FEBS Lett
; 553(1-2): 131-4, 2003 Oct 09.
Article
em En
| MEDLINE
| ID: mdl-14550560
ABSTRACT
The activity of S-adenosylmethionine decarboxylase (AdoMetDC) in Crithidia fasciculata was shown to be correlated to the growth of the parasite. An increase in activity was observed during exponential growth. Inhibition of protein synthesis induced an extremely rapid decay of AdoMetDC activity. The half-life of the enzyme was estimated to be about 3 min, which is the shortest half-life ever recorded for an eukaryotic AdoMetDC. The reduction in AdoMetDC activity was correlated with a decrease in AdoMetDC protein content, demonstrating a rapid turnover of the enzyme. No polyamine-mediated feedback regulation of AdoMetDC was observed in the parasite.
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Base de dados:
MEDLINE
Assunto principal:
Adenosilmetionina Descarboxilase
/
Crithidia fasciculata
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Suécia