G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate.
Antimicrob Agents Chemother
; 47(11): 3653-6, 2003 Nov.
Article
em En
| MEDLINE
| ID: mdl-14576140
Five sequential Cryptococcus neoformans isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-alpha lanosterol demethylase gene (ERG11) showed a point mutation in the resistant strain responsible for the amino acid substitution G484S.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxirredutases
/
Fluconazol
/
Meningite Criptocócica
/
Cryptococcus neoformans
/
Sistema Enzimático do Citocromo P-450
/
Farmacorresistência Fúngica
/
Antifúngicos
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Argentina