A new experimental model of hyperphenylalaninemia in rat. Effect of p-chlorophenylalanine and cotrimoxazole.
Biochimie
; 59(8-9): 713-7, 1977.
Article
em En
| MEDLINE
| ID: mdl-145879
ABSTRACT
A new experimental model of hyperphenylalaninemia was proposed. Combination of p.chlorophenylalanine, strongly inhibitor of phenylalanine hydroxylase, and cotrimoxazole, presumably inhibitor of dihydropteridine reductase, produced a good inhibition of phenylalanine hydroxylation in vivo. Thus phenylalaninemia reached values similar to those found in PKU patients, without administration of excess phenylalanine. Tyrosine concentrations remained near the control values and a phenylketonuria occurred.
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Base de dados:
MEDLINE
Assunto principal:
Fenilalanina
/
Fenilcetonúrias
/
Modelos Animais de Doenças
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Biochimie
Ano de publicação:
1977
Tipo de documento:
Article