Induction of myasthenia gravis in HLA transgenic mice by immunization with human acetylcholine receptors.
Ann N Y Acad Sci
; 998: 375-8, 2003 Sep.
Article
em En
| MEDLINE
| ID: mdl-14592899
ABSTRACT
We utilized HLA transgenic mice to identify the dominant epitopes on the human (H)-AChR alpha subunit. The cytoplasmic H-AChR peptide alpha320-337 was the dominant T cell epitope for DQ8, DR3, and DQ8xDQ6 F1 mice. The H-AChR-immunized HLA-DQ8, DR3, DQ8xDR3 F1 and DQ8xDQ6 F1 mice developed clinical EAMG, whereas HLA-DQ6 mice were less susceptible.
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Base de dados:
MEDLINE
Assunto principal:
Camundongos Transgênicos
/
Receptores Colinérgicos
/
Miastenia Gravis Autoimune Experimental
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Ann N Y Acad Sci
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos