Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo.
Nat Med
; 9(12): 1469-76, 2003 Dec.
Article
em En
| MEDLINE
| ID: mdl-14625545
ABSTRACT
Pathogens or pathogen-associated molecular patterns can signal to cells of the innate immune system and trigger effective adaptive immunity. However, relatively little is known about how the innate immune system detects tissue injury or necrosis. Evidence suggests that the release of heat-shock proteins (HSPs) may provide adjuvant-like signals, but the ability of HSPs to promote activation or tolerance in vivo has not been addressed. In this study we show that Hsp70 promotes dendritic cell (DC) function and, together with antigen, triggers autoimmune disease in vivo.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Proteínas de Choque Térmico HSP70
/
Células Apresentadoras de Antígenos
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Med
Assunto da revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Canadá