Transcription-coupled TA and GC strand asymmetries in the human genome.
FEBS Lett
; 555(3): 579-82, 2003 Dec 18.
Article
em En
| MEDLINE
| ID: mdl-14675777
ABSTRACT
Analysis of the whole set of human genes reveals that most of them present TA and GC skews, that these biases are correlated to each other and are specific to gene sequences, exhibiting sharp transitions between transcribed and non-transcribed regions. The GC asymmetries cannot be explained solely by a model previously proposed for (G+T) skew based on transitions measured in a small set of human genes. We propose that the GC skew results from additional transcription-coupled mutation process that would include transversions. During evolution, both processes acting on a large majority of genes in germline cells would have produced these transcription-coupled strand asymmetries.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Composição de Bases
/
Genoma Humano
Limite:
Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
França