Nonsyndromic genetic predisposition to aortic dissection: a newly recognized, diagnosable, and preventable occurrence in families.
Ann Emerg Med
; 43(1): 79-82, 2004 Jan.
Article
em En
| MEDLINE
| ID: mdl-14707946
ABSTRACT
The major diseases affecting the aorta are aortic aneurysms and dissections, with patients with acute dissections often presenting in the emergency department (ED). Recent studies demonstrate a strong genetic predisposition to thoracic aortic aneurysms and dissections, independent of syndromes traditionally considered to predispose to aortic disease (such as Marfan syndrome). Nonsyndromic familial thoracic aortic aneurysms and dissections are inherited in families as an autosomal dominant disorder and a variable age of onset of the aortic disease. The case reported here illustrates the critical importance of obtaining a family history of thoracic aortic aneurysms and dissections, along with unexplained sudden death, when assessing an individual with chest pain in the ED, regardless of age and in the absence of a known genetic syndrome.
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Base de dados:
MEDLINE
Assunto principal:
Família
/
Aneurisma da Aorta Torácica
/
Predisposição Genética para Doença
/
Serviço Hospitalar de Emergência
/
Dissecção Aórtica
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Ann Emerg Med
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos