Parallel nucleic acid recognition by the LNA (locked nucleic acid) stereoisomers beta-L-LNA and alpha-D-LNA; studies in the mirror image world.
Chem Commun (Camb)
; (3): 282-3, 2004 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-14740038
ABSTRACT
Two LNA (locked nucleic acid) stereoisomers (beta-L-LNA and alpha-D-LNA) are evaluated in the mirror-image world, that is by the study of two mixed sequences of LNA and alpha-L-LNA and their L-DNA and L-RNA complements. Both are found to display high-affinity RNA-recognition by the formation of duplexes with parallel strand orientation.
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Base de dados:
MEDLINE
Assunto principal:
RNA
/
Oligonucleotídeos Antissenso
/
Conformação de Ácido Nucleico
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Dinamarca