Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism.
Biol Psychiatry
; 55(3): 244-9, 2004 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-14744464
ABSTRACT
BACKGROUND:
A tendency to experience negative affect, as measured by the neuroticism component of the Neuroticism, Extraversion, and Openness Personality Inventory (NEO-PI), is a trait marker for major depression. Epidemiologic studies indicate a strong genetic component, but to date few specific genetic variants have been definitively implicated. A serotonin transporter promoter polymorphism (5-HTTLPR) has been extensively studied in neuroticism and several psychiatric disorders, with inconclusive results. A GABA(A) receptor alpha6 subunit variant (Pro385Ser) has been associated with alcohol-related traits but has not been studied in neuroticism or depression.METHODS:
A total of 384 subjects who completed the NEO-PI were genotyped at 5-HTTLPR and Pro385Ser. Associations between polymorphisms and both alcohol use and personality domains were tested.RESULTS:
The 5-HTTLPR short allele (p =.008) and Pro385Ser Pro allele (p =.003) are associated with higher neuroticism scores. The 5-HTTLPR long allele (p =.006), but not Pro385Ser, is also associated with an increased presence of alcohol use. In addition, there is a nonsignificant suggestion of an interaction the effect of 5-HTTLPR on neuroticism might be dependent on the Pro385Ser genotype.CONCLUSIONS:
These findings support a role for the serotonin transporter and GABA(A) alpha6 subunit in depression-related traits.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Glicoproteínas de Membrana
/
Proteínas de Transporte
/
Receptores de GABA-A
/
Proteínas do Tecido Nervoso
/
Transtornos Neuróticos
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Biol Psychiatry
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos