Identification and characterisation of constitutional chromosome abnormalities using arrays of bacterial artificial chromosomes.
Br J Cancer
; 90(4): 860-5, 2004 Feb 23.
Article
em En
| MEDLINE
| ID: mdl-14970865
ABSTRACT
Constitutional chromosome deletions and duplications frequently predispose to the development of a wide variety of cancers. We have developed a microarray of 6000 bacterial artificial chromosomes for array-based comparative genomic hybridisation, which provides an average resolution of 750 kb across the human genome. Using these arrays, subtle gains and losses of chromosome regions can be detected in constitutional cells, following a single overnight hybridisation. In this report, we demonstrate the efficiency of this procedure in identifying constitutional deletions and duplications associated with predisposition to retinoblastoma, Wilms tumour and Beckwith-Wiedemann syndrome.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Deleção Cromossômica
/
Predisposição Genética para Doença
/
Cromossomos Artificiais Bacterianos
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Br J Cancer
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos