[Hereditary renal cell carcinoma: results and place of conventional conservative surgery]. / Carcinomes à cellules rénales héréditaires: résultats de la chirurgie conservatrice conventionnelle.
Prog Urol
; 13(6): 1295-9, 2003 Dec.
Article
em Fr
| MEDLINE
| ID: mdl-15000302
ABSTRACT
OBJECTIVES:
To report the results of conservative surgery for the treatment of hereditary renal cell carcinoma (RCC) and to define its place with respect to new less invasive treatment options. MATERIAL ANDMETHOD:
Over a period of 14 years, 30 women and 26 men were operated for one or several hereditary RCC, either by radical nephrectomy or nephron-sparing excision, via a lumbar or subcostal incision, when the diameter of at least one RCC was greater than 2.5 cm.RESULTS:
92 operations were performed 62 local excisions and 30 nephrectomies. The TNM stage was 75 pT1, 14 pT2, 3 pT3b; 4 N+; 3 M+. 26 patients (46%) were operated at least twice. Two or more RCC were resected in 43 cases (47%). In the case of nephron-sparing surgery, mean blood loss was 175 +/- 231.7 cc (range 50-1300 cc); mean pedicle clamping time (97% of cases) was 32 +/- 10.4 min (range 10-50 min); mean preoperative serum creatinine was 85 +/- 18 micromol/L (range 52-150 micromol/L) and mean postoperative serum creatinine was 105 +/- 80 micromol/L (range 59-576 micromol/L); the calculated tumour recurrence rate was 24% at 5 years and 80% at 8 years; overall 5-year survival was 100% and overall 10-year survival was 67%. The median follow-up was 55.9 months.CONCLUSION:
When hereditary RCCs are situated between 2.5 cm and 6 cm in diameter, nephron-sparing surgery is the reference treatment. Modern imaging and genetic screening should allow early detection of increasingly smaller RCCs. In the future, less invasive treatment options could replace surveillance for RCCs less than 2 cm and eventually reduce the indications for local excision.
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Renais
/
Neoplasias Renais
Tipo de estudo:
Screening_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Fr
Revista:
Prog Urol
Assunto da revista:
UROLOGIA
Ano de publicação:
2003
Tipo de documento:
Article