The synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases.
Carbohydr Res
; 339(3): 699-703, 2004 Feb 25.
Article
em En
| MEDLINE
| ID: mdl-15013408
ABSTRACT
A thio-linked disaccharide based on the structure of the glycosaminoglycan chondroitin was synthesized as a potential inhibitor of chondroitin AC lyase from Flavobacterium heparinum for structural analysis of the active site. Instead it was found to be a slow substrate, thereby demonstrating that lyases, in contrast to glycosidases, can cleave thioglycoside links between sugars.
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Base de dados:
MEDLINE
Assunto principal:
Polissacarídeo-Liases
/
Compostos de Sulfidrila
/
Condroitina
/
Dissacarídeos
Idioma:
En
Revista:
Carbohydr Res
Ano de publicação:
2004
Tipo de documento:
Article