Slowing of electroencephalogram and choline acetyltransferase activity in post mortem frontal cortex in definite Alzheimer's disease.
Neuroscience
; 49(3): 529-35, 1992 Aug.
Article
em En
| MEDLINE
| ID: mdl-1501764
Twenty-five (96%) of 26 patients with histologically verified moderate to severe Alzheimer's disease had abnormal electroencephalograms. The patients with the slowest (5-6 Hz) dominant occipital rhythms had significantly lower choline acetyltransferase activity in the post mortem frontal cortex than the patients with highest rhythm (8-9 Hz) (analysis of covariance adjusted for the neuropsychological test score). Concentrations of dopamine, noradrenaline or serotonin in the frontal cortex did not differ in the patient groups with the slowest and highest rhythms. Neither did scores of senile plaques or neurofibrillary tangles differ between these groups. In Alzheimer patients, the frequency of the dominant occipital rhythm correlated with the total score of the neuropsychological test (r = 0.58, P less than 0.01) and with the subscales of praxic functions and expressive speech, memory and general reasoning. The results suggest that the cholinergic deficit may contribute to the slowing of the electroencephalogram found in patients with Alzheimer's disease.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Colina O-Acetiltransferase
/
Eletroencefalografia
/
Doença de Alzheimer
/
Lobo Frontal
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Neuroscience
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Finlândia