Subchronic toxicity study of dietary N-acetylglucosamine in F344 rats.
Food Chem Toxicol
; 42(4): 687-95, 2004 Apr.
Article
em En
| MEDLINE
| ID: mdl-15019194
ABSTRACT
A subchronic toxicity study of N-acetylglucosamine (GlcNAc), a monomeric form of chitin, was conducted in groups of 10 male and 10 female F344 rats fed pelleted diets containing 0, 0.625, 1.25, 2.5 or 5% concentrations for 13 weeks. All animals survived until the end of the experiment. Slight, non-significant increase in body weights was observed in males receiving 0.625, 1.25 or 2.5% from week 4 until the end of the experiment, when significant elevation was found for the males receiving 0.625, 1.25 or 2.5% at the terminal sacrifice to result in decreased relative weights of many organs in these cases. However, there were no obvious indications of toxicity in any group receiving GlcNAc in terms of clinical signs, food intake, hematology, serum biochemistry, and histopathological findings. Thus, it was concluded that orally administered GlcNAc exerts no obvious toxicity to F344 rats at concentrations up to 5% in the diet for 13 weeks. Based on the present toxicity data, > or =5% was determined to be a no-observed-adverse-effect level, translated into 2476 and 2834 mg/kg/day for male and female rats, respectively.
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Base de dados:
MEDLINE
Assunto principal:
Acetilglucosamina
Limite:
Animals
Idioma:
En
Revista:
Food Chem Toxicol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Japão