Rescue of cells from apoptosis by antioxidants occurs downstream from GSH extrusion.
Ann N Y Acad Sci
; 1010: 441-5, 2003 Dec.
Article
em En
| MEDLINE
| ID: mdl-15033767
ABSTRACT
Antioxidants-that is, scavengers of free radicals and anaerobic conditions (5%CO(2), 95% N(2))-protect monocytic U937 cells from damage-induced apoptosis. Antioxidants rescue the cells acting on the apoptotic pathway at a step downstream from gluthatione extrusion. Reducing agents, such as DTT, also reduce stress-induced apoptosis. Thus, apoptotic GSH extrusion triggers the downstream events of apoptosis by leaving cells unprotected against thiol\s oxidation and radical production.
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Base de dados:
MEDLINE
Assunto principal:
Apoptose
/
Glutationa
/
Antioxidantes
Limite:
Humans
Idioma:
En
Revista:
Ann N Y Acad Sci
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Itália