Mutations in ribonuclease L gene do not occur at a greater frequency in patients with familial prostate cancer compared with patients with sporadic prostate cancer.
Clin Prostate Cancer
; 2(3): 177-80, 2003 Dec.
Article
em En
| MEDLINE
| ID: mdl-15040862
ABSTRACT
Several genetic loci are suspected to be involved in hereditary prostate cancer, including the hereditary prostate cancer 1 (HPC1) locus at chromosome 1q24-25. The ribonuclease L (RNase L) gene has been reported as the putative hereditary prostate cancer gene located at HPC1. If this is the case, mutations of RNase L should be found at a greater frequency in familial cancers than in sporadic prostate cancers. Examination of familial and sporadic cases of prostate cancer by polymerase chain reaction and DNA sequencing resulted in a mutational frequency rate that was not statistically different between the 2 forms of the disease. These results suggest that the mutations examined within this study are rare and may contribute to very few familial prostate cancers.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Ribonucleases
/
Mutação
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Prostate Cancer
Assunto da revista:
NEOPLASIAS
/
UROLOGIA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos