Farnesyloxycoumarins, a new class of squalene-hopene cyclase inhibitors.
Bioorg Med Chem Lett
; 14(8): 1931-4, 2004 Apr 19.
Article
em En
| MEDLINE
| ID: mdl-15050630
ABSTRACT
A few naturally occurring prenyl- and prenyloxycoumarins and several new related synthetic derivatives were evaluated as inhibitors of squalene-hopene cyclase (SHC), a useful model enzyme, to predict their interactions with oxidosqualene cyclase (OSC). Umbelliprenin-10',11'-monoepoxide (IC(50) 2.5 microM) and the corresponding 6',7'-10',11' diepoxide (IC(50) 1.5 microM) were the most active enzyme inhibitors.
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Base de dados:
MEDLINE
Assunto principal:
Transferases Intramoleculares
/
Cumarínicos
/
Inibidores Enzimáticos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Itália