[Expression of macrophage colony stimulating factor in brains of PDAPPV717I transgenic mice].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
; 26(1): 62-5, 2004 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-15052777
ABSTRACT
OBJECTIVE:
To identify the expression and distribution of macrophage colony stimulating factor (M-CSF) in brains of PDAPPV717I transgenic mice.METHODS:
We detected the expression and distribution of M-CSF mRNA in brains of PDAPPV717I transgenic mice by using hybridization in situ and immunohistochemical staining.RESULTS:
Expression of M-CSF mRNA was significantly higher in brains of PDAPPV717I transgenic mice than that in non-transgenic mice, and M-CSF mRNA in brain was mainly produced by reactive astrocytes.CONCLUSION:
The results indicate that astrocytes play an important role in the onset/development of neuropathology of Alzheimer's disease.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Fator Estimulador de Colônias de Macrófagos
/
Doença de Alzheimer
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
China