Aneurysmal bone cyst: a hereditary disease?
J Pediatr Orthop B
; 13(3): 214-7, 2004 May.
Article
em En
| MEDLINE
| ID: mdl-15083125
ABSTRACT
Recent genetic and immunohistochemical studies propose that the primary aneurysmal bone cyst is a tumour and not a reactive tumour-simulating lesion. Based on a familial case of aneurysmal bone cyst the authors contacted 135 patients with this disease. Sixty-eight females and 67 males (median age 14 years; range 2-73 years) were asked if other family members had bone lesions. One hundred and seven patients (79%) denied having other family members with lesions, 23 patients (17%) did not answer, and five patients (4%) gave evidence of other bone lesions in the family. These data indicate that a predisposing genetic defect could be part of a multifactorial pathogenesis in the development of some aneurysmal bone cysts.
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Base de dados:
MEDLINE
Assunto principal:
Cistos Ósseos Aneurismáticos
/
Predisposição Genética para Doença
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Pediatr Orthop B
Assunto da revista:
ORTOPEDIA
/
PEDIATRIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Áustria