A novel means of identifying the neuraminidase type of currently circulating human A(H1) influenza viruses.
Virus Res
; 103(1-2): 79-83, 2004 Jul.
Article
em En
| MEDLINE
| ID: mdl-15163493
ABSTRACT
With the recent emergence and spread of influenza A(H1N2) viruses which appear to have arisen by reassortment of circulating A(H1N1) and A(H3N2) strains, there is a need in epidemiological studies to determine the neuraminidase type in order to differentiate between influenza A(H1N2) and A(H1N1) strains. A fluorescence-based neuraminidase enzyme inhibition assay that has been developed to screen influenza viruses for potential resistance to the neuraminidase inhibitor drugs appears to be suitable for this purpose. When used with the neuraminidase inhibitor zanamivir the assay was able to provide a positive predictive value of 93.5% for the identification of neuraminidase type N1 or N2. This assay enables a large number of influenza A viruses to be screened at low cost to determine relative levels of A(H1N2) or A(H1N1) viruses circulating in the population.
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Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
/
Neuraminidase
Tipo de estudo:
Evaluation_studies
Limite:
Humans
Idioma:
En
Revista:
Virus Res
Assunto da revista:
VIROLOGIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Austrália