Ultrasound abnormalities preceding cerebral palsy in high-risk preterm infants.
J Pediatr
; 144(6): 815-20, 2004 Jun.
Article
em En
| MEDLINE
| ID: mdl-15192633
ABSTRACT
OBJECTIVE:
To assess sequential high-resolution cranial ultrasound (US) in high-risk preterm infants to predict cerebral palsy (CP). STUDYDESIGN:
Preterm infants were prospectively studied (n=2139), 1636RESULTS:
Seventy-six (5%) of the 1460 survivors in group A developed CP. US abnormalities were present in 70 of 76 (92%) infants, being major in 58 (83%) and minor in 12 (17%). In 29% of the CP cases with major US abnormalities, cysts were first detected beyond day 28. A further 6 infants without US abnormalities developed CP, and 3 of these infants developed ataxic CP. Twenty-nine (6%) of the 469 survivors in group B developed CP. US abnormalities were present in 28 of 29 (96%) infants, being major in 25 (89%) and minor in 3 (11%). One infant without US abnormalities developed CP. Considering the major US abnormalities, a specificity of 95% and 99% and a sensitivity of 76% and 86% were found for group A and B, respectively. The positive predictive value was 48% in group A and 83% in group B.CONCLUSION:
Seventy-nine percent of our CP cases had major US abnormalities. To detect c-PVL, the most predictive US marker for CP, sequential scans with a 7.5-MHz transducer are required.
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Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Prematuro
/
Ecoencefalografia
/
Paralisia Cerebral
/
Transtornos Cerebrovasculares
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Newborn
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Pediatr
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Holanda