Proteome analysis of the causative agent of Chagas disease: Trypanosoma cruzi.
Int J Parasitol
; 34(8): 881-6, 2004 Jul.
Article
em En
| MEDLINE
| ID: mdl-15217726
ABSTRACT
Trypanosoma cruzi, the causative agent of Chagas disease, has evolved particular mechanisms of gene regulation. Gene expression is regulated firstly at post-transcriptional level. This feature makes proteomic methods a promising tool for studying adaptative changes in these parasites. In this work we generated a reproducible method for protein analysis by two-dimensional electrophoresis coupled to mass spectrometry, and a protein map for T. cruzi. Western-blot analysis supported the identity of some of the proteins. This work points to proteomic approach as a powerful tool to study differential expression, stress response or drug resistance in T. cruzi.
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Base de dados:
MEDLINE
Assunto principal:
Trypanosoma cruzi
/
Proteínas de Protozoários
/
Doença de Chagas
/
Proteoma
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Parasitol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Uruguai