Participation of caudal ventrolateral medulla in the regulation of gallbladder motility in rabbits.
Chin J Physiol
; 47(1): 1-6, 2004 Mar 31.
Article
em En
| MEDLINE
| ID: mdl-15239588
ABSTRACT
To investigate whether the caudal ventrolateral medulla (CVLM) participates in the regulation of gallbladder motility, we studied the effects of microinjection of L-glutamate and other agents into the CVLM on gallbladder pressure (GP) in anesthetized rabbits. A frog bladder connected with a force transducer was inserted into the gallbladder to record the change of GP. Microinjection of L-glutamate into the CVLM decreased GP, While micnoinjection of gamma-amino-butyric acid (GABA) increased GP. Microinjection of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, into CVLM increased GP, while microinjection of 6-cyano-7-nitroquinoxaline-2,3-(1H,4H)-dione (CNQX), a competitive (+/-)-a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptor antagonist, had no significant effect on GP. The effects of L-glutamate was abolished by ketamine, but not by CNQX. Intravenous injection of phentolamine or transection of the spinal cord eliminated the effects of L-glutamate on GP. These results indicate that [1] CVLM participated in the regulation of gallbladder motility; [2] endogenous L-glutamate in CVLM is involved in the regulation mediated by NMDA receptors, the output of which is sent through sympathetic nerve and alpha-adrenergic receptors.
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Base de dados:
MEDLINE
Assunto principal:
Bulbo
/
Esvaziamento da Vesícula Biliar
/
Receptores de N-Metil-D-Aspartato
/
Ácido Glutâmico
/
Ácido gama-Aminobutírico
Limite:
Animals
Idioma:
En
Revista:
Chin J Physiol
Ano de publicação:
2004
Tipo de documento:
Article