Dynamics of biological molecules irradiated by short x-ray pulses.
Phys Rev E Stat Nonlin Soft Matter Phys
; 69(5 Pt 1): 051906, 2004 May.
Article
em En
| MEDLINE
| ID: mdl-15244846
ABSTRACT
Very short and intense x-ray pulses can be used for diffraction imaging of single biological molecules. Inevitably, x-ray absorption initiates damage that degrades the molecule's image. This paper presents a continuum model of the physics that leads to damage when a small particle absorbs a large x-ray dose. The main processes are found to be ionization and Coulomb-force driven atomic motion. Trapping of electrons, Debye shielding, and nonuniform collisional ionization all have a significant effect on the overall damage kinetics.
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Base de dados:
MEDLINE
Assunto principal:
Raios X
/
Biofísica
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Phys Rev E Stat Nonlin Soft Matter Phys
Assunto da revista:
BIOFISICA
/
FISIOLOGIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos