[Effect of antiischemic therapy in immediate period after mammary coronary bypass surgery on left ventricular contractility and conduit blood flow. Randomized controlled study]. / Vliianie antiishemicheskoi terapii v blizhaishem periode posle mammarno-koronarnogo shuntirovaniia na sokratitel'nuiu funktsiiu levogo zheludochka i krovotok po mammarno-koronarnym shuntam: randomizirovannoe platsebo-kontroliruemoe issledovanie.

ABSTRACT

AIM: To assess influence of 2-week course therapy with atenolol, nebivolol, and verapamil on systolic and diastolic left ventricular function and mammary coronary blood flow in early period after revascularization. MATERIAL: Patients (n=113) after mammary coronary bypass grafting. METHODS: Echocardiographic characteristics of systolic and diastolic left ventricular function, and blood flow through mammary coronary grafts were measured before and after treatment with study drugs. RESULTS: In placebo treated patients isovolumic relaxation time (IVRT) and late diastolic filling phase (A) increased, while velocity characteristics of mammary-coronary blood flow decreased. Administration of atenolol, nebivolol, and verapamil was associated with significant increases of left ventricular ejection fraction, stroke volume, cardiac output, IVRT, peak diastolic velocity, flow through mammary coronary grafts and their lumen diameter, and decrease of E/A ratio. CONCLUSION: Administration of atenolol, nebivolol, and verapamil in early postoperative period after mammary coronary bypass grafting improved systolic and diastolic function of the left ventricle, and blood flow through mammary coronary grafts. None of the studied drugs had significant advantage over others.