[Diffusing capacity for carbon monoxide (T(LCO)) and oxygen saturation during exercise in patients with cystic fibrosis]. / Capacité de transfert du monoxyde de carbone (TLCO) et saturation artérielle à l'exercice chez les patients atteints de mucoviscidose.
Arch Pediatr
; 11(9): 1060-6, 2004 Sep.
Article
em Fr
| MEDLINE
| ID: mdl-15350995
OBJECTIVES: To estimate the value of diffusing capacity for carbon monoxide (T(LCO)) in patients with cystic fibrosis and to evaluate its ability to predict arterial desaturation during exercise. METHOD: Fourty-four patients (9-30 years) with cystic fibrosis performed pulmonary function tests with measure of T(LCO) and a bicycle incremental exercise test. They represent a wide variation in disease severity: mean Shwachman score: 77.8 (range: 40-100), mean FEV1%: 72.8 (range: 17-131). This study investigated the relationship between T(LCO), lung volumes and exercise data. RESULTS: T(LCO) remained normal for a long time in patients with cystic fibrosis: 82% of them show a normal T(LCO) (mean value: 91.3% of predicted). T(LCO) was significantly correlated with FEV(1), residual volume, maximal work load and maximum oxygen uptake. A fall in arterial oxygen saturation was uncommon in our study (five patients) and not significantly correlated with T(LCO). CONCLUSIONS: T(LCO) is a good criter of severity of cystic fibrosis but remains unreliable to predict values above which physical activity is safe, without arterial desaturation. Exercise tests should be proposed in order to evaluate exercise adaptation of each patient and determine which factor limits maximal performance.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Monóxido de Carbono
/
Exercício Físico
/
Capacidade de Difusão Pulmonar
/
Fibrose Cística
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Idioma:
Fr
Revista:
Arch Pediatr
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
França