Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy.
AIDS
; 18(9): 1335-7, 2004 Jun 18.
Article
em En
| MEDLINE
| ID: mdl-15362667
ABSTRACT
Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-1-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-alpha levels and the amelioration of clonogenic parameters.
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Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Hematopoéticas
/
Infecções por HIV
/
HIV-1
Limite:
Humans
Idioma:
En
Revista:
AIDS
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Itália