Plasma B-type natriuretic peptide reflects left ventricular hypertrophy and diastolic function in hypertension.
Int J Cardiol
; 97(2): 251-6, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15458692
ABSTRACT
BACKGROUND:
Hypertension is associated with changes in concentrations of vasoactive peptides and procollagen propeptides, but their relationships with left ventricular hypertrophy and cardiac function are unclear.METHODS:
We measured plasma levels of atrial natriuretic peptide (ANP), its amino terminal propeptide (NT-proANP), B-type natriuretic peptide (BNP), endothelin-1 (ET-1), and serum levels of the aminoterminal propeptide of type I procollagen (PINP) and the aminoterminal propeptide of type III procollagen (PIIINP) and echocardiographic parameters in 97 patients with hypertension in the Anglo-Scandinavian Cardiac Outcomes Trial.RESULTS:
Median values (reference values) of the peptides were ANP 11.2 (6.9-14.9) pmol/l, NT-proANP 351 (143-311) pmol/l, BNP 1.1 (0.4-7.2) pmol/l, ET-1 8.7 (1.2-5.0) pmol/l, PIIINP 2.8 (1.7-4.2) microg/l and PINP 29 (19-84) microg/l. Plasma BNP levels in patients with left ventricular hypertrophy (1.2 pmol/l) and patients with echocardiographic signs of diastolic dysfunction (1.5 pmol/l) were greater than those in patients without hypertrophy (0.7 pmol/l) and normal diastolic parameters (0.9 pmol/l) (p<0.05). BNP was the only biochemical parameter that independently predicted interventricular septal diastolic diameter (p<0.05), left ventricular mass index (p<0.01) and ratio of the velocity-time integrals of the E and A waves of the mitral inflow in a stepwise logistic regression analysis (p<0.05).CONCLUSIONS:
The results show that BNP reflects the remodelling process in hypertension.
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Base de dados:
MEDLINE
Assunto principal:
Hipertrofia Ventricular Esquerda
/
Disfunção Ventricular Esquerda
/
Peptídeo Natriurético Encefálico
/
Hipertensão
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Int J Cardiol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Finlândia