Histopathological changes of cervical tissue in women with systemic sclerosis.
Pathol Int
; 54(10): 759-64, 2004 Oct.
Article
em En
| MEDLINE
| ID: mdl-15482565
ABSTRACT
Systemic sclerosis is a connective tissue disease that can affect almost any organ of the body. The clinical aspects of systemic sclerosis on the reproductive system have been studied in large series, and an increased rate of cesarean section has been reported. For this reason, in the present study the histopathological features of cervical specimens of hysterectomyzed women with systemic sclerosis were evaluated. An increased frequency of vascular and stromal abnormalities in cervical specimens of women with systemic sclerosis were observed. Vascular medial hypertrophy, intimal thickening, and fibrosis were more often encountered in the cervical specimens of the patients with systemic sclerosis. Some of the histopathological features also showed correlation with the clinical profile of the disease. The patients with vascular medial hypertrophy in their cervical specimens were older, had a higher Rodnan score, and had longer duration of the disease. In contrast to vascular medial hypertrophy, periadventitial edema was found in the cervical specimens of the patients who were younger, had a lower Rodnan score, and had shorter duration of the disease. It was concluded that the problems that are seen in common obstetric and gynecological practices in patients with systemic sclerosis may be explained by these tissue abnormalities.
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Base de dados:
MEDLINE
Assunto principal:
Escleroderma Sistêmico
/
Doenças do Colo do Útero
/
Colo do Útero
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Pathol Int
Assunto da revista:
PATOLOGIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Turquia