The androgenic profile of women with non-insulin-dependent diabetes mellitus.
J Reprod Med
; 49(9): 746-52, 2004 Sep.
Article
em En
| MEDLINE
| ID: mdl-15493567
ABSTRACT
OBJECTIVE:
To evaluate the androgenic profile of women with non-insulin-dependent diabetes mellitus. STUDYDESIGN:
This case-control study evaluated the clinical, hormonal and ultrasonographic characteristics of women of reproductive age with non-insulin-dependent diabetes mellitus and compared them with those of age- and weight-matched controls. Radioimmunoassays were used for total testosterone, estradiol, dehydroepiandrosterone sulfate (DHEAS) and androstenedione. Sex hormone-binding globulin (SHBG), luteinizing hormone (LH) and follicle stimulating hormone (FSH) were analyzed by fluoroimmunoassays. Ovarian appearance and volume were assessed by transvaginal or transabdominal ultrasonography.RESULTS:
The prevalence of polycystic ovary syndrome was higher in diabetic patients than in the general population as reported earlier. Hirsutism was also more prevalent in diabetic patients (p < 0.05). The serum levels of FSH, LH, estradiol, total testosterone, androstenedione and DHEAS were significantly higher in diabetic patients than in the control group (p < 0.05). In contrast, the levels of SHBG were lower in diabetic patients (p < 0.05). The rates of ultrasonographically apparent polycystic ovaries and greater ovarian volumes were also higher in diabetic patients (p < 0.05).CONCLUSION:
Women with non-insulin-dependent diabetes mellitus seem to have biochemical and clinical hyperandrogenism when compared with nondiabetic controls.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
/
Hormônios Esteroides Gonadais
/
Hiperandrogenismo
/
Diabetes Mellitus Tipo 2
/
Hirsutismo
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Reprod Med
Ano de publicação:
2004
Tipo de documento:
Article