Polymorphisms in equine immune response genes and their associations with infections.
Mamm Genome
; 15(10): 843-50, 2004 Oct.
Article
em En
| MEDLINE
| ID: mdl-15520887
Polymorphic markers identified in the horse genes encoding the interleukin 12 p40 subunit, interferon gamma, tumor necrosis factor receptor 1, and inducible nitric oxide synthase were identified and tested, along with additional markers, for associations with two important horse infections: Rhodococcus equi and Lawsonia intracellularis. Eight immune response-related and 14 microsatellite loci covering 12 out of 31 equine autosomes were used for the association analysis. Markers located on horse Chromosomes Eca10 and 15 were significantly associated with the presence of high numbers of R. equi in transtracheal aspirates. Significant associations of markers located on Eca9, 15, and 21 with fecal shedding of Lawsonia intracellularis were found. Marginal associations with tumor necrosis factor alpha, interferon gamma, and other genes suggested that variations in immune response-related genes could underlie the phenotypic variation observed.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Interferon gama
/
Genes MHC da Classe II
/
Predisposição Genética para Doença
/
Cavalos
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Mamm Genome
Assunto da revista:
GENETICA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
República Tcheca