Synthesis and phloem mobility of acidic derivatives of the fungicide fenpiclonil.
Pest Manag Sci
; 60(11): 1063-72, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15532679
ABSTRACT
A series of derivatives of the phenylpyrrole fungicide fenpiclonil was synthesized in which a carboxyl group was present at various sites of this non-phloem-mobile molecule. Using the Kleier model, all these acidic analogues were predicted to be moderately phloem-mobile, especially the N-substituted derivatives. One of these latter molecules, N-carboxymethyl-3-cyano-4-(2,3-dichlorophenyl)pyrrole, exhibited some fungicidal activity on the pathogenic fungus Eutypa lata, and was then tested as a phloem-mobile pesticide in the Ricinus system. The compound was indeed mobile in the sieve tubes and was not degraded to fenpiclonil in the phloem sap under our experimental conditions. Its concentration in the sap was closely correlated to the percentage of the undissociated form of the molecule in the external medium, and was similar under acidic conditions (external pH 4.6-5.0) to that of the herbicide glyphosate.
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Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Pirróis
/
Ricinus
/
Brotos de Planta
/
Fungicidas Industriais
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Pest Manag Sci
Assunto da revista:
TOXICOLOGIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
França