Methyl jasmonate induces apoptosis through induction of Bax/Bcl-XS and activation of caspase-3 via ROS production in A549 cells.
Oncol Rep
; 12(6): 1233-8, 2004 Dec.
Article
em En
| MEDLINE
| ID: mdl-15547743
ABSTRACT
Jasmonates are plant lipid derivatives, similar to mammalian eicosanoid, that play a critical role(s) in plant defenses against herbivores and pathogens through up-regulating the expression of defense-related genes. Recently, jasmonates were shown to induce cell cycle arrest or apoptosis in human leukemia, prostate and breast cancer cells, but not in normal lymphocytes, suggesting that the chemicals can be used as a novel class of anti-cancer drugs. In the present study, we examined the molecular mechanism that contributes to methyl jasmonate-induced apoptosis. Herein we show that methyl jasmonate induces apoptosis through induction of Bax/Bcl-XS and activation of caspase-3 via reactive oxygen species production in A549 human lung adenocarcinoma cells.
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Base de dados:
MEDLINE
Assunto principal:
Reguladores de Crescimento de Plantas
/
Espécies Reativas de Oxigênio
/
Apoptose
/
Proteínas Proto-Oncogênicas c-bcl-2
/
Ciclopentanos
/
Acetatos
Limite:
Humans
Idioma:
En
Revista:
Oncol Rep
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2004
Tipo de documento:
Article