[Gamma-hydroxybutyrate--a neurotransmitter, medicine, and drug]. / Gamma-hydroxybuttersäure--Neurotransmitter, Medikament und Droge.
Nervenarzt
; 76(7): 832, 834-8, 2005 Jul.
Article
em De
| MEDLINE
| ID: mdl-15580464
ABSTRACT
Gamma-hydroxybutyrate (GHB) is a short fatty acid and physiologic neurotransmitter. Initially, it was synthesized as a GABA agonist and used as a narcotic agent, because it rapidly induces sleep without major cardiovascular or respiratory side effects. Recently, a specific GHB receptor was identified, but while the clinical use of GHB as an anaesthetic was reduced due to putative pro-convulsive effects, it now is used to treat alcohol withdrawal and sleep disorders. Furthermore, GHB was postulated to be a regulator of energy metabolism, and tissue-protective effects were demonstrated in different animal models. Besides its clinical use, GHB (also called "liquid ecstasy") is increasingly consumed in the disco scene because of its mild sedative and euphoric effects. Intoxication from GHB is common with GHB users. For this reason and because GHB is not easy to detect, it is important to be aware of the symptoms of GHB intoxication. Moreover, some recent case reports document the danger of GHB dependence.
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Base de dados:
MEDLINE
Assunto principal:
Transtornos do Sono-Vigília
/
Oxibato de Sódio
/
Transtornos Relacionados ao Uso de Substâncias
Limite:
Humans
Idioma:
De
Revista:
Nervenarzt
Ano de publicação:
2005
Tipo de documento:
Article