Role of synaptic inhibition in spatiotemporal patterning of cortical activity.
Prog Brain Res
; 147: 201-4, 2005.
Article
em En
| MEDLINE
| ID: mdl-15581707
ABSTRACT
Developmental upregulation of the GABAA receptor alpha1 subunit causes a faster decay of GABAergic inhibitory postsynaptic currents (IPSCs) in the visual cortex around the time of eye opening. In alpha1 deficient mice, a juvenile type of GABAA receptors is retained during maturation. As a result the decay time of the IPSCs is longer in alpha1-/- mice than in WT mice during the whole life span of the mice. Hence they form a valuable mouse model for studies on cellular aspects of neuronal network functioning. Using voltage sensitive dye imaging methods, we monitored the spatiotemporal excitation patterning in visual cortex slices upon local stimulation of the network. We found that in the alpha1-/- mice, the ability of the network to fire synchronously at gamma-frequencies (20-50 Hz) is diminished. This finding indicates that early onset of GABA synapse maturation is required for the normal neuronal network function in the maturating visual cortex.
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Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Córtex Visual
/
Ácido gama-Aminobutírico
/
Rede Nervosa
/
Inibição Neural
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Prog Brain Res
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Holanda