In vitro efficacy of new antiprotozoals against Philasterides dicentrarchi (Ciliophora, Scuticociliatida).
Dis Aquat Organ
; 62(1-2): 97-102, 2004 Nov 23.
Article
em En
| MEDLINE
| ID: mdl-15648836
ABSTRACT
Philasterides dicentrarchi is a histiophagous ciliate that causes severe losses in turbot and sea bass farming. This study investigated the in vitro efficacy against P. dicentrarchi of 85 newly synthesized compounds and 12 commercial compounds, of which 2 are fluoroquinolones (norfloxacine and lomefloxacine) with known antibacterial activity. Seventeen of the newly synthesized compounds (2 naphthyridines, 2 pyridothienodiazines and 13 pyridothienotriazines) and the fluoroquinolone norfloxacin showed good activity. The most promising compound was the pyridothienotriazine 12k, with activity similar to that of the salicylanilides niclosamide and oxiclozanide (MLC 0.8 mg l(-1) in PBS, 1.5 mg l(-1) in seawater; MLC = minimum 24 h lethal concentration).
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Base de dados:
MEDLINE
Assunto principal:
Oligoimenóforos
/
Infecções por Cilióforos
/
Doenças dos Peixes
/
Peixes
/
Antiprotozoários
Limite:
Animals
Idioma:
En
Revista:
Dis Aquat Organ
Assunto da revista:
BIOLOGIA
/
MEDICINA VETERINARIA
/
MICROBIOLOGIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Espanha