Oxidative modification of leukocyte adhesion.

ABSTRACT

In this issue of Immunity, Marko Salmi and colleagues describe mice lacking AOC3, an endothelial cell monoaminooxidase that is involved in modulating leukocyte rolling, adhesion, and migration (Stolen et al., 2005). Their data demonstrate the importance of oxidative modification of (unknown) adhesion molecules in regulating inflammation and lymphocyte homing.